Version 5.4
Homo sapiens Gene: KRT4
Summary
InnateDB Gene IDBG-35080.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT4
Gene Name keratin 4
Synonyms CK-4; CK4; CYK4; K4; WSN1
Species Homo sapiens
Ensembl Gene ENSG00000170477
Encoded Proteins
IDBP-600391
keratin 4
IDBP-586665
keratin 4
IDBP-591669
keratin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52806549-52814551
Strand Reverse strand
Band q13.13
Transcripts
ENST00000551956 ENSP00000448220
ENST00000548097 ENSP00000449755
ENST00000549295
ENST00000552668 ENSP00000447320
ENST00000551436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0030855 epithelial cell differentiation
GO:0050680 negative regulation of epithelial cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005882 intermediate filament
GO:0009986 cell surface
GO:0045095 keratin filament
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059668
View Gene Order
ENSBTAG00000012034
Not yet available
Cross-References
SwissProt
TrEMBL F8VX05
UniProt Splice Variant
Entrez Gene 3851
UniGene Hs.654610 Hs.736109
RefSeq NM_002272
HUGO HGNC:6441
OMIM 123940
CCDS CCDS41787
HPRD 00478
IMGT
EMBL AC107016
GenPept
RNA Seq Atlas 3851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca