Version 5.4
Homo sapiens Gene: UBE2G1
Summary
InnateDB Gene IDBG-18727.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2G1
Gene Name ubiquitin-conjugating enzyme E2G 1
Synonyms E217K; UBC7; UBE2G
Species Homo sapiens
Ensembl Gene ENSG00000132388
Encoded Proteins
IDBP-236360
ubiquitin-conjugating enzyme E2G 1
IDBP-763630
IDBP-760683
IDBP-762524
IDBP-758084
IDBP-763299
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:4269259-4366628
Strand Reverse strand
Band p13.2
Transcripts
ENST00000396981 ENSP00000380178
ENST00000574633 ENSP00000458253
ENST00000571980 ENSP00000459847
ENST00000572484 ENSP00000459691
ENST00000571953 ENSP00000467502
ENST00000574059 ENSP00000459485
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008152 metabolic process
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020794
View Gene Order
ENSBTAG00000014433
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05012
Parkinson's disease pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL I3L0Q0 I3L2Q4
UniProt Splice Variant
Entrez Gene 7326
UniGene Hs.462035 Hs.741319
RefSeq NM_003342
HUGO HGNC:12482
OMIM 601569
CCDS CCDS32532
HPRD 03340
IMGT
EMBL AC087742 AC116910
GenPept
RNA Seq Atlas 7326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca