Version 5.4
Mus musculus Gene: Plekhg4
Summary
InnateDB Gene IDBG-187604.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plekhg4
Gene Name pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Synonyms 4931414L13Rik; AI448583; mFLJ00068
Species Mus musculus
Ensembl Gene ENSMUSG00000014782
Encoded Proteins
IDBP-187606
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
IDBP-541348
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
IDBP-538310
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
IDBP-536657
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196155:
The protein encoded by this gene contains multiple domains suggestive of a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Mutations in this gene are associated with spinocerebellar ataxia 16q22-linked. Several alternatively spliced transcript variants, differing only in the 5' UTR, or encoding a different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene contains multiple domains suggestive of a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Mutations in this gene are associated with spinocerebellar ataxia 16q22-linked. Several alternatively spliced transcript variants, differing only in the 5\' UTR, or encoding a different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105373274-105382862
Strand Forward strand
Band D3
Transcripts
ENSMUST00000014927 ENSMUSP00000014927
ENSMUST00000160650 ENSMUSP00000124061
ENSMUST00000159286 ENSMUSP00000125556
ENSMUST00000160191 ENSMUSP00000125249
ENSMUST00000161672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0008150 biological_process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196155
View Gene Order
ENSBTAG00000021570
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.488804
RefSeq NM_001081333 XM_006530525
OMIM
CCDS CCDS40458
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca