Homo sapiens Gene: MUC5B
Summary
InnateDB Gene IDBG-18918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUC5B
Gene Name mucin 5B, oligomeric mucus/gel-forming
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117983
Encoded Proteins
mucin 5B, oligomeric mucus/gel-forming
mucin 5B, oligomeric mucus/gel-forming
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:1223066-1262172
Strand Forward strand
Band p15.5
Transcripts
ENST00000525715
ENST00000529681 ENSP00000436812
ENST00000531082
ENST00000526859 ENSP00000434539
ENST00000527802
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
O-linked glycosylation of mucins pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
Termination of O-glycan biosynthesis pathway
KEGG
Salivary secretion pathway
INOH
PID BIOCARTA
Nfkb activation by nontypeable hemophilus influenzae [Biocarta view]
PID NCI
Cross-References
SwissProt Q9HC84
TrEMBL E9PBJ0 Q93043
UniProt Splice Variant
Entrez Gene 727897
UniGene Hs.523395
RefSeq NM_002458
HUGO HGNC:7516
OMIM 600770
CCDS CCDS44515
HPRD
IMGT
EMBL AC061979 AF086604 AF107890 AH006676 AJ004862 S80993 U63836 U78551 U95031 X74955 Y09788 Z72496
GenPept AAB35930 AAB61398 AAB65151 AAC51343 AAC51344 AAC67545 AAG33673 CAA06167 CAA52910 CAA70926 CAA96577
RNA Seq Atlas 727897