Version 5.4
Homo sapiens Gene: GINS4
Summary
InnateDB Gene IDBG-18945.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GINS4
Gene Name GINS complex subunit 4 (Sld5 homolog)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147536
Encoded Proteins
IDBP-18947
GINS complex subunit 4 (Sld5 homolog)
IDBP-473818
GINS complex subunit 4 (Sld5 homolog)
IDBP-482268
GINS complex subunit 4 (Sld5 homolog)
IDBP-474234
GINS complex subunit 4 (Sld5 homolog)
IDBP-476411
GINS complex subunit 4 (Sld5 homolog)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:41529206-41545046
Strand Forward strand
Band p11.21
Transcripts
ENST00000276533 ENSP00000276533
ENST00000520354 ENSP00000429894
ENST00000520710 ENSP00000429581
ENST00000520631
ENST00000520736
ENST00000518671 ENSP00000428754
ENST00000523277 ENSP00000428901
ENST00000522642
ENST00000518430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031546
View Gene Order
ENSBTAG00000017133
Not yet available
Pathways
NETPATH
REACTOME
REACT_6776
Unwinding of DNA pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.656996 Hs.706190
RefSeq NM_032336 XM_005273659
HUGO
OMIM
CCDS CCDS6116
HPRD 11583
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca