Homo sapiens Gene: GINS4
Summary
InnateDB Gene IDBG-18945.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GINS4
Gene Name GINS complex subunit 4 (Sld5 homolog)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147536
Encoded Proteins
GINS complex subunit 4 (Sld5 homolog)
GINS complex subunit 4 (Sld5 homolog)
GINS complex subunit 4 (Sld5 homolog)
GINS complex subunit 4 (Sld5 homolog)
GINS complex subunit 4 (Sld5 homolog)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:41529206-41545046
Strand Forward strand
Band p11.21
Transcripts
ENST00000276533 ENSP00000276533
ENST00000520354 ENSP00000429894
ENST00000520710 ENSP00000429581
ENST00000520631
ENST00000520736
ENST00000518671 ENSP00000428754
ENST00000523277 ENSP00000428901
ENST00000522642
ENST00000518430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
S Phase pathway
Unwinding of DNA pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.656996 Hs.706190
RefSeq NM_032336 XM_005273659
HUGO
OMIM
CCDS CCDS6116
HPRD 11583
IMGT
EMBL
GenPept
RNA Seq Atlas