Mus musculus Gene: Hnrnpa1
Summary
InnateDB Gene IDBG-189480.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnrnpa1
Gene Name heterogeneous nuclear ribonucleoprotein A1
Synonyms Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1;
Species Mus musculus
Ensembl Gene ENSMUSG00000046434
Encoded Proteins
heterogeneous nuclear ribonucleoprotein A1
heterogeneous nuclear ribonucleoprotein A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135486:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:103240432-103244955
Strand Forward strand
Band F3
Transcripts
ENSMUST00000087351 ENSMUSP00000084609
ENSMUST00000036004 ENSMUSP00000042658
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 214 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 214 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0008380 RNA splicing
GO:0051028 mRNA transport
GO:0051168 nuclear export
GO:0051170 nuclear import
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0019013 viral nucleocapsid
GO:0030529 ribonucleoprotein complex
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular vesicular exosome
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
IL6 pathway
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
Cross-References
SwissProt P49312
TrEMBL
UniProt Splice Variant
Entrez Gene 545091
UniGene Mm.237064 Mm.368204 Mm.391346 Mm.402576 Mm.403156 Mm.452234 Mm.489546
RefSeq NM_010447 NM_001039129
OMIM
CCDS CCDS37233 CCDS37232
HPRD
IMGT
MGI ID MGI:104820
MGI Symbol Hnrnpa1
EMBL AK007802 AK088308 AK131999 AK135391 AK161730 AK166901 AK167161 AK167810 AK167913 AK168420 AK168531 BC080675 BC083136 D86728 D86729 M99167
GenPept AAA37633 AAH80675 AAH83136 BAA13161 BAA13162 BAB25267 BAC40273 BAE20929 BAE22518 BAE36552 BAE39104 BAE39302 BAE39837 BAE39920 BAE40333 BAE40409
RNA Seq Atlas 15382 545091