Version 5.4
Mus musculus Protein: Hnrnpa1
Summary
InnateDB Protein IDBP-176171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnrnpa1
Protein Name heterogeneous nuclear ribonucleoprotein A1
Synonyms Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1;
Species Mus musculus
Ensembl Protein ENSMUSP00000084609
InnateDB Gene IDBG-189480 (Hnrnpa1)
Protein Structure
UniProt Annotation
Function Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.
Subcellular Localization Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 214 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 214 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
Biological Process
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0008380 RNA splicing
GO:0051028 mRNA transport
GO:0051168 nuclear export
GO:0051170 nuclear import
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:104820
InterPro IPR000504 RNA recognition motif domain
IPR021662 Nuclear factor hnRNPA1
PFAM PF00076
PF11627
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49312
PhosphoSite PhosphoSite-P49312
TrEMBL
UniProt Splice Variant
Entrez Gene 545091
UniGene Mm.489546
RefSeq NP_034577
MGI ID
MGI Symbol Hnrnpa1
OMIM
CCDS CCDS37233
HPRD
IMGT
EMBL AK007802 AK088308 AK131999 AK135391 AK161730 AK166901 AK167161 AK167810 AK167913 AK168420 AK168531 BC080675 BC083136 D86728 D86729 M99167
GenPept AAA37633 AAH80675 AAH83136 BAA13161 BAA13162 BAB25267 BAC40273 BAE20929 BAE22518 BAE36552 BAE39104 BAE39302 BAE39837 BAE39920 BAE40333 BAE40409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca