Mus musculus Gene: Vwf | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-189967.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Vwf | ||||||||||||||||||||||
Gene Name | Von Willebrand factor homolog | ||||||||||||||||||||||
Synonyms | 6820430P06Rik; AI551257; B130011O06Rik; C630030D09; F8VWF; VWD | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000001930 | ||||||||||||||||||||||
Encoded Proteins |
Von Willebrand factor homolog
Von Willebrand factor homolog
Von Willebrand factor homolog
Von Willebrand factor homolog
Von Willebrand factor homolog
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110799:
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand\'s disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 6:125546774-125686679 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | F3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Platelet degranulation pathway
GP1b-IX-V activation signalling pathway
Hemostasis pathway
Extracellular matrix organization pathway
Platelet activation, signaling and aggregation pathway
Intrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet Adhesion to exposed collagen pathway
Integrin cell surface interactions pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
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KEGG |
ECM-receptor interaction pathway
Complement and coagulation cascades pathway
Focal adhesion pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Platelet Adhesion to exposed collagen pathway
Intrinsic Pathway pathway
GP1b-IX-V activation signalling pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Integrin cell surface interactions pathway
Extracellular matrix organization pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Hemostasis pathway
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KEGG |
Complement and coagulation cascades pathway
ECM-receptor interaction pathway
Focal adhesion pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.22339 | ||||||||||||||||||||||
RefSeq | NM_011708 XM_006505917 XM_006505918 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS20552 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||