InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VWF

Summary

InnateDB Gene

IDBG-640531.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VWF

Gene Name

von Willebrand factor precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012265

Encoded Proteins

IDBP-692911

von Willebrand factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110799:
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand\'s disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:104603432-104727301

Strand

Forward strand

Band

Transcripts

ENSBTAT00000016273

ENSBTAP00000016273

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0002020	protease binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019865	immunoglobulin binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0047485	protein N-terminus binding
GO:0051087	chaperone binding

Biological Process

GO:0001889	liver development
GO:0001890	placenta development
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0030168	platelet activation
GO:0031589	cell-substrate adhesion
GO:0051260	protein homooligomerization

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0009897	external side of plasma membrane
GO:0031012	extracellular matrix
GO:0033093	Weibel-Palade body
GO:0070062	extracellular vesicular exosome