Bos taurus Gene: VWF | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-640531.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | VWF | ||||||||||||||||||||||
Gene Name | von Willebrand factor precursor | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000012265 | ||||||||||||||||||||||
Encoded Proteins |
von Willebrand factor
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110799:
The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand\'s disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:104603432-104727301 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Platelet Adhesion to exposed collagen pathway
Intrinsic Pathway pathway
GP1b-IX-V activation signalling pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Integrin cell surface interactions pathway
Extracellular matrix organization pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Hemostasis pathway
Platelet degranulation pathway
GP1b-IX-V activation signalling pathway
Hemostasis pathway
Extracellular matrix organization pathway
Platelet activation, signaling and aggregation pathway
Intrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet Adhesion to exposed collagen pathway
Integrin cell surface interactions pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Response to elevated platelet cytosolic Ca2+ pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
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KEGG |
Complement and coagulation cascades pathway
ECM-receptor interaction pathway
Focal adhesion pathway
ECM-receptor interaction pathway
Complement and coagulation cascades pathway
Focal adhesion pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | F1N0R5 Q7JJ73 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 280958 | ||||||||||||||||||||||
UniGene | Bt.35003 | ||||||||||||||||||||||
RefSeq | NM_001205308 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF004285 DAAA02014492 DAAA02014493 DAAA02014494 DAAA02014495 DAAA02014496 DAAA02014497 | ||||||||||||||||||||||
GenPept | AAB61376 | ||||||||||||||||||||||
RNA Seq Atlas | 280958 | ||||||||||||||||||||||