Version 5.4
Homo sapiens Gene: ALOX15
Summary
InnateDB Gene IDBG-19074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALOX15
Gene Name arachidonate 15-lipoxygenase
Synonyms 12-LOX; 15-LOX-1; 15LOX-1
Species Homo sapiens
Ensembl Gene ENSG00000161905
Encoded Proteins
IDBP-19078
arachidonate 15-lipoxygenase
IDBP-758568
IDBP-763863
IDBP-761006
IDBP-760814
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:4630902-4642294
Strand Reverse strand
Band p13.2
Transcripts
ENST00000293761 ENSP00000293761
ENST00000574640 ENSP00000460483
ENST00000573740
ENST00000572265 ENSP00000460430
ENST00000570836 ENSP00000458832
ENST00000576572
ENST00000576394 ENSP00000458630
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004052 arachidonate 12-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
GO:0047977 hepoxilin-epoxide hydrolase activity
GO:0050473 arachidonate 15-lipoxygenase activity
GO:0051120 hepoxilin A3 synthase activity
GO:0097260 eoxin A4 synthase activity
Biological Process
GO:0001503 ossification
GO:0002820 negative regulation of adaptive immune response
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0006691 leukotriene metabolic process
GO:0006954 inflammatory response
GO:0010811 positive regulation of cell-substrate adhesion
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0030282 bone mineralization
GO:0030838 positive regulation of actin filament polymerization
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034976 response to endoplasmic reticulum stress
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035963 cellular response to interleukin-13
GO:0042060 wound healing
GO:0043277 apoptotic cell clearance
GO:0044281 small molecule metabolic process
GO:0051122 hepoxilin biosynthetic process
GO:0055114 oxidation-reduction process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071277 cellular response to calcium ion
GO:1901074 regulation of engulfment of apoptotic cell
GO:2001303 lipoxin A4 biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018924
View Gene Order
ENSBTAG00000011990
Not yet available
Pathways
NETPATH
REACTOME
REACT_150422
Synthesis of 15-eicosatetraenoic acid derivatives pathway
REACT_150420
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
REACT_150201
Synthesis of 12-eicosatetraenoic acid derivatives pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt P16050
TrEMBL B7ZA11 D3DTK1 F5H0G8 I3L175
UniProt Splice Variant
Entrez Gene 246
UniGene Hs.549540 Hs.644589 Hs.73809
RefSeq NM_001140
HUGO HGNC:433
OMIM 152392
CCDS CCDS11049
HPRD
IMGT
EMBL AC118754 AK290309 AK316126 AY505111 BC029032 CH471108 M23892 U63384 U88317
GenPept AAA36182 AAB49305 AAC52118 AAH29032 AAR84235 BAF82998 BAH14497 EAW90427 EAW90428
RNA Seq Atlas 246

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca