Homo sapiens Gene: P2RX6
Summary
InnateDB Gene IDBG-1914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX6
Gene Name purinergic receptor P2X, ligand-gated ion channel, 6
Synonyms P2RXL1; P2X6; P2XM;
Species Homo sapiens
Ensembl Gene ENSG00000099957
Encoded Proteins
purinergic receptor P2X, ligand-gated ion channel, 6
purinergic receptor P2X, ligand-gated ion channel, 6
purinergic receptor P2X, ligand-gated ion channel, 6
purinergic receptor P2X, ligand-gated ion channel, 6
purinergic receptor P2X, ligand-gated ion channel, 6
purinergic receptor P2X, ligand-gated ion channel, 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:21009808-21028830
Strand Forward strand
Band q11.21
Transcripts
ENST00000401443 ENSP00000385309
ENST00000442475 ENSP00000401192
ENST00000413302 ENSP00000416193
ENST00000452228 ENSP00000398347
ENST00000432930 ENSP00000404223
ENST00000422210 ENSP00000407920
ENST00000469722
ENST00000487342
ENST00000591411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015267 channel activity
GO:0042802 identical protein binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0034220 ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:0055085 transmembrane transport
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.113275
RefSeq NM_001159554 NM_005446 XM_005261819 XM_006724369
HUGO
OMIM
CCDS CCDS13788 CCDS54504
HPRD 08490
IMGT
EMBL
GenPept
RNA Seq Atlas