InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: P2RX6

Summary

InnateDB Gene

IDBG-1914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RX6

Gene Name

purinergic receptor P2X, ligand-gated ion channel, 6

Synonyms

P2RXL1; P2X6; P2XM

Species

Homo sapiens

Ensembl Gene

ENSG00000099957

Encoded Proteins

IDBP-292642

purinergic receptor P2X, ligand-gated ion channel, 6

IDBP-364515

purinergic receptor P2X, ligand-gated ion channel, 6

IDBP-364552

purinergic receptor P2X, ligand-gated ion channel, 6

IDBP-364554

purinergic receptor P2X, ligand-gated ion channel, 6

IDBP-364557

purinergic receptor P2X, ligand-gated ion channel, 6

IDBP-364559

purinergic receptor P2X, ligand-gated ion channel, 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:21009808-21028830

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000401443	ENSP00000385309
ENST00000442475	ENSP00000401192
ENST00000413302	ENSP00000416193
ENST00000452228	ENSP00000398347
ENST00000432930	ENSP00000404223
ENST00000422210	ENSP00000407920
ENST00000469722
ENST00000487342
ENST00000591411

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005216	ion channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015267	channel activity
GO:0042802	identical protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006936	muscle contraction
GO:0007165	signal transduction
GO:0034220	ion transmembrane transport
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization
GO:0055085	transmembrane transport

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0043025	neuronal cell body
GO:0043197	dendritic spine

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022758

View Gene Order

ENSBTAG00000019244

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.113275

RefSeq

NM_001159554 NM_005446 XM_005261819 XM_006724369

HUGO

OMIM

CCDS

CCDS13788 CCDS54504

HPRD

08490

IMGT

EMBL

GenPept

RNA Seq Atlas