InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KDR

Summary

InnateDB Gene

IDBG-19161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDR

Gene Name

kinase insert domain receptor (a type III receptor tyrosine kinase)

Synonyms

CD309; FLK1; VEGFR; VEGFR2

Species

Homo sapiens

Ensembl Gene

ENSG00000128052

Encoded Proteins

IDBP-19165

kinase insert domain receptor (a type III receptor tyrosine kinase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24270517

[Mus musculus] Mir126-Kdr axis is an important regulator of the innate response. Mir126 controls the survival and function of plasmacytoid dendritic cells and regulates gene expression of Tlr7, Tlr9, Nfkb1 and Kdr.

PMID 24270517

[Mus musculus] Mir126 controls the IFN-α/β responses to pathogen-associated nucleic acids through regulating the homeostasis and function of plasmacytoid dendritic cells (pDCs). Mir126 operates in part by regulating Kdr which encodes the growth factor receptor VEGFR2 in pDCs

Entrez Gene

Summary

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:55078477-55125589

Strand

Reverse strand

Band

q12

Transcripts

ENST00000263923	ENSP00000263923
ENST00000509309
ENST00000512566

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0038085	vascular endothelial growth factor binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001541	ovarian follicle development
GO:0001570	vasculogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001945	lymph vessel development
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0003158	endothelium development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0010595	positive regulation of endothelial cell migration
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032	viral process
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030097	hemopoiesis
GO:0030198	extracellular matrix organization
GO:0030324	lung development
GO:0030335	positive regulation of cell migration
GO:0035162	embryonic hemopoiesis
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043129	surfactant homeostasis
GO:0043410	positive regulation of MAPK cascade
GO:0045165	cell fate commitment
GO:0045446	endothelial cell differentiation
GO:0045766	positive regulation of angiogenesis
GO:0046777	protein autophosphorylation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048286	lung alveolus development
GO:0048469	cell maturation
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050927	positive regulation of positive chemotaxis
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0051894	positive regulation of focal adhesion assembly
GO:0055074	calcium ion homeostasis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2000352	negative regulation of endothelial cell apoptotic process
GO:2001214	positive regulation of vasculogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005768	endosome
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0045121	membrane raft
GO:0071944	cell periphery
GO:0097443	sorting endosome