Homo sapiens Gene: OLIG2
Summary
InnateDB Gene IDBG-1917.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OLIG2
Gene Name oligodendrocyte lineage transcription factor 2
Synonyms BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17;
Species Homo sapiens
Ensembl Gene ENSG00000205927
Encoded Proteins
oligodendrocyte lineage transcription factor 2
oligodendrocyte lineage transcription factor 2
oligodendrocyte lineage transcription factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:33025845-33029196
Strand Forward strand
Band q22.11
Transcripts
ENST00000382357 ENSP00000371794
ENST00000333337 ENSP00000331040
ENST00000430860 ENSP00000391183
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046983 protein dimerization activity
GO:0071837 HMG box domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0021522 spinal cord motor neuron differentiation
GO:0021529 spinal cord oligodendrocyte cell differentiation
GO:0021530 spinal cord oligodendrocyte cell fate specification
GO:0021794 thalamus development
GO:0042552 myelination
GO:0045665 negative regulation of neuron differentiation
GO:0048663 neuron fate commitment
GO:0048709 oligodendrocyte differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
ID pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.176977 Hs.732068
RefSeq NM_005806
HUGO
OMIM
CCDS CCDS13620
HPRD 07334
IMGT
EMBL
GenPept
RNA Seq Atlas