InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dyrk2

Summary

InnateDB Gene

IDBG-192216.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dyrk2

Gene Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Synonyms

1810038L18Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028630

Encoded Proteins

IDBP-192218

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127334:
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5\' terminal insert. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:118859349-118868903

Strand

Reverse strand

Band

Transcripts

ENSMUST00000004281

ENSMUSP00000004281

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030145	manganese ion binding
GO:0043130	ubiquitin binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007224	smoothened signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0051534	negative regulation of NFAT protein import into nucleus

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000127334

View Gene Order

ENSBTAG00000007256

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53regulationpathway

p53 pathway

Cross-References

SwissProt

Q5U4C9

TrEMBL

UniProt Splice Variant

Entrez Gene

69181

UniGene

Mm.458174 Mm.481769

RefSeq

NM_001014390 XM_006514046

OMIM

CCDS

CCDS24201

HPRD

IMGT

MGI ID

MGI:1330301

MGI Symbol

Dyrk2

EMBL

BC085145

GenPept

AAH85145

RNA Seq Atlas

69181