Version 5.4
Homo sapiens Gene: DYRK2
Summary
InnateDB Gene IDBG-45841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYRK2
Gene Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127334
Encoded Proteins
IDBP-45843
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
IDBP-45845
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
IDBP-243395
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
IDBP-588006
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
IDBP-584818
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5\' terminal insert. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:67648338-67665406
Strand Forward strand
Band q15
Transcripts
ENST00000344096 ENSP00000342105
ENST00000319833 ENSP00000324733
ENST00000393555 ENSP00000377186
ENST00000543747 ENSP00000440839
ENST00000537632
ENST00000542503 ENSP00000443314
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
Experimentally validated
Total 57 [view]
Protein-Protein 55 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030145 manganese ion binding
GO:0043130 ubiquitin binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007224 smoothened signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0051534 negative regulation of NFAT protein import into nucleus
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028630
View Gene Order
ENSBTAG00000007256
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt Q92630
TrEMBL F5GXG1
UniProt Splice Variant
Entrez Gene 8445
UniGene Hs.173135 Hs.606656 Hs.618871 Hs.732280 Hs.733040
RefSeq NM_003583 NM_006482
HUGO HGNC:3093
OMIM 603496
CCDS CCDS8979 CCDS8978
HPRD 04606
IMGT
EMBL AC078777 AK313937 BC005809 BC006375 CH471054 Y09216 Y13493
GenPept AAH05809 AAH06375 BAG36656 CAA70418 CAA73885 EAW97176
RNA Seq Atlas 8445

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca