Homo sapiens Gene: POM121
InnateDB Gene IDBG-19260.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POM121
Gene Name POM121 transmembrane nucleoporin
Synonyms P145; POM121A
Species Homo sapiens
Ensembl Gene ENSG00000196313
Encoded Proteins
POM121 membrane glycoprotein
POM121 membrane glycoprotein
POM121 membrane glycoprotein
POM121 membrane glycoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and multiple pseudogenes have been identified. [provided by RefSeq, Mar 2012]
This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:72879365-72951440
Strand Forward strand
Band q11.23
ENST00000358357 ENSP00000351124
ENST00000395270 ENSP00000378687
ENST00000446813 ENSP00000393020
ENST00000434423 ENSP00000405562
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000278 mitotic cell cycle
GO:0005975 carbohydrate metabolic process
GO:0007077 mitotic nuclear envelope disassembly
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0015031 protein transport
GO:0015758 glucose transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0044281 small molecule metabolic process
GO:0051028 mRNA transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005789 endoplasmic reticulum membrane
GO:0031965 nuclear membrane
No orthologs found for this gene
ISG15 antiviral mechanism pathway
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
Glucose transport pathway
Hexose transport pathway
Nuclear import of Rev protein pathway
Vpr-mediated nuclear import of PICs pathway
Rev-mediated nuclear export of HIV RNA pathway
Viral Messenger RNA Synthesis pathway
Late Phase of HIV Life Cycle pathway
Transmembrane transport of small molecules pathway
Influenza Infection pathway
Interactions of Vpr with host cellular proteins pathway
Myoclonic epilepsy of Lafora pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Metabolism of carbohydrates pathway
Transcriptional regulation by small RNAs pathway
Nuclear Pore Complex (NPC) Disassembly pathway
Influenza Viral RNA Transcription and Replication pathway
Interferon Signaling pathway
Cell Cycle pathway
Immune System pathway
M Phase pathway
HIV Life Cycle pathway
Mitotic Prophase pathway
Cell Cycle, Mitotic pathway
HIV Infection pathway
Influenza Life Cycle pathway
Metabolism pathway
Host Interactions of HIV factors pathway
SLC-mediated transmembrane transport pathway
Interactions of Rev with host cellular proteins pathway
Gene Expression pathway
Nuclear Envelope Breakdown pathway
Disease pathway
Glycogen storage diseases pathway
Regulatory RNA pathways pathway
RNA transport pathway
UniProt Splice Variant
Entrez Gene
UniGene Hs.655217
RefSeq NM_001257190 NM_172020 XM_005250726 XM_005250728 XM_005250729 XM_005250730 XM_005250731 XM_005250732 XM_006716194 XM_006716195 XM_006716196
HPRD 11448
RNA Seq Atlas