InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POM121

Summary

InnateDB Protein

IDBP-19637.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POM121

Protein Name

POM121 membrane glycoprotein

Synonyms

P145; POM121A;

Species

Homo sapiens

Ensembl Protein

ENSP00000351124

InnateDB Gene

IDBG-19260 (POM121)

Protein Structure

UniProt Annotation

Function

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269PubMed:17900573}.

Subcellular Localization

Nucleus, nuclear pore complex {ECO:0000269PubMed:17900573}. Nucleus membrane {ECO:0000269PubMed:17900573}; Single-pass membrane protein {ECO:0000269PubMed:17900573}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0051028	mRNA transport
GO:0055085	transmembrane transport