InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VRK1

Summary

InnateDB Gene

IDBG-19297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VRK1

Gene Name

vaccinia related kinase 1

Synonyms

PCH1; PCH1A

Species

Homo sapiens

Ensembl Gene

ENSG00000100749

Encoded Proteins

IDBP-19299

vaccinia related kinase 1

IDBP-592478

vaccinia related kinase 1

IDBP-598143

vaccinia related kinase 1

IDBP-597799

vaccinia related kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:96797304-96931722

Strand

Forward strand

Band

q32.2

Transcripts

ENST00000216639	ENSP00000216639
ENST00000555351
ENST00000557222	ENSP00000450820
ENST00000557352	ENSP00000451682
ENST00000555067
ENST00000553683	ENSP00000451412
ENST00000555402

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031493	nucleosomal histone binding
GO:0035175	histone kinase activity (H3-S10 specific)
GO:0072354	histone kinase activity (H3-T3 specific)

Biological Process

GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0007077	mitotic nuclear envelope disassembly
GO:0007084	mitotic nuclear envelope reassembly
GO:0043987	histone H3-S10 phosphorylation
GO:0046777	protein autophosphorylation
GO:0072355	histone H3-T3 phosphorylation
GO:0090166	Golgi disassembly