Homo sapiens Gene: VRK1
Summary
InnateDB Gene IDBG-19297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VRK1
Gene Name vaccinia related kinase 1
Synonyms PCH1; PCH1A;
Species Homo sapiens
Ensembl Gene ENSG00000100749
Encoded Proteins
vaccinia related kinase 1
vaccinia related kinase 1
vaccinia related kinase 1
vaccinia related kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:96797304-96931722
Strand Forward strand
Band q32.2
Transcripts
ENST00000216639 ENSP00000216639
ENST00000555351
ENST00000557222 ENSP00000450820
ENST00000557352 ENSP00000451682
ENST00000555067
ENST00000553683 ENSP00000451412
ENST00000555402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031493 nucleosomal histone binding
GO:0035175 histone kinase activity (H3-S10 specific)
GO:0072354 histone kinase activity (H3-T3 specific)
Biological Process
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0007077 mitotic nuclear envelope disassembly
GO:0007084 mitotic nuclear envelope reassembly
GO:0043987 histone H3-S10 phosphorylation
GO:0046777 protein autophosphorylation
GO:0072355 histone H3-T3 phosphorylation
GO:0090166 Golgi disassembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005819 spindle
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Initiation of Nuclear Envelope Reformation pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Mitotic Prophase pathway
Nuclear Envelope Reassembly pathway
Cell Cycle, Mitotic pathway
Nuclear Envelope Breakdown pathway
Clearance of Nuclear Envelope Membranes from Chromatin pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 7443
UniGene Hs.422662 Hs.622262
RefSeq NM_003384
HUGO HGNC:12718
OMIM 602168
CCDS CCDS9947
HPRD 03701
IMGT
EMBL
GenPept
RNA Seq Atlas 7443