Version 5.4
Mus musculus Gene: Epb4
Summary
InnateDB Gene IDBG-193371.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Epb4
Gene Name erythrocyte protein band 4.1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028906
Encoded Proteins
IDBP-193373
erythrocyte protein band 4.1
IDBP-193375
erythrocyte protein band 4.1
IDBP-193379
erythrocyte protein band 4.1
IDBP-269729
erythrocyte protein band 4.1
IDBP-269735
erythrocyte protein band 4.1
IDBP-269737
erythrocyte protein band 4.1
IDBP-269739
erythrocyte protein band 4.1
IDBP-269741
erythrocyte protein band 4.1
IDBP-539552
erythrocyte protein band 4.1
IDBP-542721
erythrocyte protein band 4.1
IDBP-533593
erythrocyte protein band 4.1
IDBP-536649
erythrocyte protein band 4.1
IDBP-533145
erythrocyte protein band 4.1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159023:
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:131923413-132075321
Strand Reverse strand
Band D2.3
Transcripts
ENSMUST00000054917 ENSMUSP00000060375
ENSMUST00000084253 ENSMUSP00000081274
ENSMUST00000030739 ENSMUSP00000030739
ENSMUST00000105981 ENSMUSP00000101601
ENSMUST00000105975 ENSMUSP00000101595
ENSMUST00000105974 ENSMUSP00000101594
ENSMUST00000105972 ENSMUSP00000101592
ENSMUST00000105970 ENSMUSP00000101590
ENSMUST00000146021
ENSMUST00000135579 ENSMUSP00000121764
ENSMUST00000137846 ENSMUSP00000123623
ENSMUST00000151746
ENSMUST00000146443 ENSMUSP00000122234
ENSMUST00000155990 ENSMUSP00000116599
ENSMUST00000144754
ENSMUST00000141291 ENSMUSP00000120236
ENSMUST00000136761
ENSMUST00000131953
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 101 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 101 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005545 1-phosphatidylinositol binding
GO:0008092 cytoskeletal protein binding
GO:0030507 spectrin binding
Biological Process
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0030866 cortical actin cytoskeleton organization
GO:0032092 positive regulation of protein binding
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
GO:0030863 cortical cytoskeleton
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159023
View Gene Order
ENSBTAG00000006667
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
Cross-References
SwissProt
TrEMBL Q3U0G7
UniProt Splice Variant
Entrez Gene 269587
UniGene Mm.471627 Mm.484693
RefSeq NM_001128606 NM_001128607 NM_183428 XM_006538908 XM_006538911 XM_006538912 XM_006538918 XM_006538919
OMIM
CCDS CCDS18717 CCDS51317
HPRD
IMGT
MGI ID MGI:95401
MGI Symbol Epb4.1
EMBL AK156891
GenPept BAE33886
RNA Seq Atlas 269587

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca