Version 5.4
Bos taurus Gene: BT.87209
Summary
InnateDB Gene IDBG-644847.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.87209
Gene Name protein 4.1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006667
Encoded Proteins
IDBP-697523
protein 4.1
IDBP-697526
protein 4.1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159023:
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:125014818-125113212
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008765 ENSBTAP00000008765
ENSBTAT00000008760 ENSBTAP00000008760
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.
Predicted by orthology
Total 96 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0030866 cortical actin cytoskeleton organization
GO:0032092 positive regulation of protein binding
Cellular Component
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000159023
View Gene Order
ENSMUSG00000028906
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04530
Tight junction pathway
mmu04530
Tight junction pathway
INOH
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.87209
RefSeq NM_174311
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca