InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apip

Summary

InnateDB Gene

IDBG-193760.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apip

Gene Name

APAF1 interacting protein

Synonyms

APIP2; CGI-29; Mmrp19

Species

Mus musculus

Ensembl Gene

ENSMUSG00000010911

Encoded Proteins

IDBP-193762

APAF1 interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149089:
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:103073675-103092644

Strand

Forward strand

Band

Transcripts

ENSMUST00000011055	ENSMUSP00000011055
ENSMUST00000124540
ENSMUST00000155004
ENSMUST00000147131

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding
GO:0046570	methylthioribulose 1-phosphate dehydratase activity
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0019284	L-methionine biosynthetic process from S-adenosylmethionine
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0043066	negative regulation of apoptotic process
GO:0070372	regulation of ERK1 and ERK2 cascade