Version 5.4
Homo sapiens Gene: APIP
Summary
InnateDB Gene IDBG-39476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APIP
Gene Name APAF1 interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149089
Encoded Proteins
IDBP-238844
APAF1 interacting protein
IDBP-806597
APAF1 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:34853094-34916499
Strand Reverse strand
Band p13
Transcripts
ENST00000395787 ENSP00000379133
ENST00000532428 ENSP00000474191
ENST00000527830
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046570 methylthioribulose 1-phosphate dehydratase activity
GO:0046872 metal ion binding
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0006595 polyamine metabolic process
GO:0006915 apoptotic process
GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine
GO:0019509 L-methionine biosynthetic process from methylthioadenosine
GO:0034641 cellular nitrogen compound metabolic process
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000010911
View Gene Order
ENSBTAG00000018257
Not yet available
Pathways
NETPATH
REACTOME
REACT_75881
Methionine salvage pathway pathway
REACT_14820
Metabolism of polyamines pathway
REACT_115639
Sulfur amino acid metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00270
Cysteine and methionine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.600666
RefSeq NM_015957
HUGO
OMIM
CCDS CCDS7895
HPRD 14725
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca