InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ryk

Summary

InnateDB Gene

IDBG-194079.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ryk

Gene Name

receptor-like tyrosine kinase

Synonyms

AW536699; ERK-3; Vik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032547

Encoded Proteins

IDBP-194081

receptor-like tyrosine kinase

IDBP-742250

IDBP-741893

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163785:
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:102834917-102908305

Strand

Forward strand

Band

Transcripts

ENSMUST00000035142	ENSMUSP00000035142
ENSMUST00000176573
ENSMUST00000175788
ENSMUST00000175883	ENSMUSP00000135858
ENSMUST00000177274
ENSMUST00000176198	ENSMUSP00000135396

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017147	Wnt-protein binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0016055	Wnt signaling pathway
GO:0022038	corpus callosum development
GO:0030182	neuron differentiation
GO:0031175	neuron projection development
GO:0043410	positive regulation of MAPK cascade
GO:0048705	skeletal system morphogenesis
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0071679	commissural neuron axon guidance