Version 5.4
Homo sapiens Gene: RYK
Summary
InnateDB Gene IDBG-57467.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RYK
Gene Name receptor-like tyrosine kinase
Synonyms D3S3195; JTK5; JTK5A; RYK1
Species Homo sapiens
Ensembl Gene ENSG00000163785
Encoded Proteins
IDBP-811631
receptor-like tyrosine kinase
IDBP-485090
RYK receptor-like tyrosine kinase
IDBP-485392
RYK receptor-like tyrosine kinase
IDBP-811637
receptor-like tyrosine kinase
IDBP-811640
receptor-like tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:134065303-134250744
Strand Reverse strand
Band q22.2
Transcripts
ENST00000472234 ENSP00000475203
ENST00000460933 ENSP00000419122
ENST00000473208
ENST00000486725 ENSP00000417836
ENST00000481382
ENST00000480381
ENST00000464879
ENST00000623711 ENSP00000485095
ENST00000620660 ENSP00000478721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 72 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017147 Wnt-protein binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0016055 Wnt signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0022038 corpus callosum development
GO:0030182 neuron differentiation
GO:0031175 neuron projection development
GO:0048705 skeletal system morphogenesis
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0050919 negative chemotaxis
GO:0071679 commissural neuron axon guidance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032547
View Gene Order
ENSBTAG00000016999
Not yet available
Pathways
NETPATH
NetPath_8
Wnt pathway
REACTOME
KEGG
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
wnt_signaling_pathway
Wnt signaling network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654562
RefSeq NM_001005861 NM_002958
HUGO
OMIM
CCDS CCDS75016
HPRD 02751
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca