Mus musculus Gene: Maf
Summary
InnateDB Gene IDBG-194495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Maf
Gene Name avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
Synonyms 2810401A20Rik; A230108G15Rik; AW047063; c-maf;
Species Mus musculus
Ensembl Gene ENSMUSG00000055435
Encoded Proteins
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178573:
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:115682942-115707794
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000069009 ENSMUSP00000067704
ENSMUST00000109104 ENSMUSP00000104732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 7 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001816 cytokine production
GO:0002088 lens development in camera-type eye
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010628 positive regulation of gene expression
GO:0032330 regulation of chondrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048839 inner ear development
GO:0070306 lens fiber cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
PID NCI
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
AP-1 transcription factor network
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.275549 Mm.416112 Mm.439772 Mm.453171
RefSeq NM_001025577
OMIM
CCDS CCDS40486
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas