Mus musculus Protein: Maf | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-194497.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Maf | ||||||||||||||||||||||
Protein Name | avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog | ||||||||||||||||||||||
Synonyms | 2810401A20Rik; A230108G15Rik; AW047063; c-maf; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000067704 | ||||||||||||||||||||||
InnateDB Gene | IDBG-194495 (Maf) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)- mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf- responsive element binding. {ECO:0000250, ECO:0000269PubMed:10097114, ECO:0000269PubMed:10383433, ECO:0000269PubMed:10403649, ECO:0000269PubMed:10603348, ECO:0000269PubMed:11943779, ECO:0000269PubMed:14512017, ECO:0000269PubMed:17823980, ECO:0000269PubMed:17897790, ECO:0000269PubMed:17901057, ECO:0000269PubMed:19143053, ECO:0000269PubMed:9070273, ECO:0000269PubMed:9566892}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in tubules of the renal cortex and hepatocytes. Expressed in the lens (at protein level). Expressed in pancreatic islets and endothelial cells. {ECO:0000269PubMed:15249232, ECO:0000269PubMed:17897790, ECO:0000269PubMed:17901057}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:96909 | ||||||||||||||||||||||
InterPro |
IPR004826
Basic leucine zipper domain, Maf-type IPR004827 Basic-leucine zipper domain IPR008917 Transcription factor, Skn-1-like, DNA-binding domain IPR013592 Maf transcription factor, N-terminal |
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PFAM |
PF03131
PF00170 PF07716 PF08383 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00338
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P54843 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P54843 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 17132 | ||||||||||||||||||||||
UniGene | Mm.453171 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Maf | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC113301 AK132165 AY560005 S74567 | ||||||||||||||||||||||
GenPept | AAB32820 AAY81957 BAE21007 | ||||||||||||||||||||||