Homo sapiens Gene: POLR1D
Summary
InnateDB Gene IDBG-19480.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR1D
Gene Name polymerase (RNA) I polypeptide D, 16kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186184
Encoded Proteins
polymerase (RNA) I polypeptide D, 16kDa
polymerase (RNA) I polypeptide D, 16kDa
polymerase (RNA) I polypeptide D, 16kDa
polymerase (RNA) I polypeptide D, 16kDa
polymerase (RNA) I polypeptide D, 16kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:27620743-27667422
Strand Forward strand
Band q12.2
Transcripts
ENST00000302979 ENSP00000302478
ENST00000399697 ENSP00000382604
ENST00000399696 ENSP00000382603
ENST00000465887
ENST00000489647 ENSP00000483656
ENST00000472179
ENST00000621089 ENSP00000478213
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006383 transcription from RNA polymerase III promoter
GO:0006385 transcription elongation from RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0010467 gene expression
GO:0032481 positive regulation of type I interferon production
GO:0045087 innate immune response
Cellular Component
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005736 DNA-directed RNA polymerase I complex
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TNFalpha pathway
REACTOME
RNA Polymerase I Transcription pathway
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
RNA Polymerase III Transcription Initiation pathway
RNA Polymerase I Promoter Escape pathway
RNA Polymerase III Transcription Termination pathway
Innate Immune System pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
RNA Polymerase I Transcription Termination pathway
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
RNA Polymerase III Chain Elongation pathway
Immune System pathway
RNA Polymerase III Transcription pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Transcription Initiation pathway
RNA Polymerase III Abortive And Retractive Initiation pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Cytosolic sensors of pathogen-associated DNA pathway
Gene Expression pathway
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
Negative epigenetic regulation of rRNA expression pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
RNA polymerase pathway
Cytosolic DNA-sensing pathway pathway
INOH
PID BIOCARTA
Tumor suppressor arf inhibits ribosomal biogenesis [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.507584
RefSeq NM_001206559 NM_015972 NM_152705 XM_005266412 XM_005266414
HUGO
OMIM
CCDS CCDS73555 CCDS9324 CCDS9325
HPRD 17877
IMGT
EMBL
GenPept
RNA Seq Atlas