Version 5.4
Homo sapiens Gene: TLE3
Summary
InnateDB Gene IDBG-19521.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLE3
Gene Name transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
Synonyms ESG; ESG3; GRG3; HsT18976
Species Homo sapiens
Ensembl Gene ENSG00000140332
Encoded Proteins
IDBP-19523
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-376492
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-376495
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-584798
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-603601
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-591136
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-590387
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-603036
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-596473
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-592984
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-596040
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-590754
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-585317
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-592765
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-602709
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-600565
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-589171
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-587584
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
IDBP-746488
IDBP-745376
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:70047790-70098176
Strand Reverse strand
Band q23
Transcripts
ENST00000317509 ENSP00000319233
ENST00000451782 ENSP00000394717
ENST00000440567 ENSP00000415057
ENST00000558939 ENSP00000452871
ENST00000557919 ENSP00000452803
ENST00000560525 ENSP00000453219
ENST00000557815
ENST00000560589 ENSP00000454141
ENST00000559929 ENSP00000453081
ENST00000559048 ENSP00000453760
ENST00000560939 ENSP00000452933
ENST00000557997 ENSP00000453083
ENST00000561453 ENSP00000453373
ENST00000559608
ENST00000539550 ENSP00000442594
ENST00000558201 ENSP00000452881
ENST00000559191 ENSP00000454029
ENST00000557907 ENSP00000453107
ENST00000558379 ENSP00000453435
ENST00000542329
ENST00000559826
ENST00000557984 ENSP00000452809
ENST00000560996 ENSP00000457641
ENST00000537387 ENSP00000456178
ENST00000559574
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 29 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007219 Notch signaling pathway
GO:0009887 organ morphogenesis
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032280
View Gene Order
ENSBTAG00000015580
Not yet available
Pathways
NETPATH
REACTOME
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228106
repression of WNT target genes pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Wnt signaling pathway pathway
INOH website
TGF-beta signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.287362 Hs.604506 Hs.604666 Hs.732737
RefSeq NM_001105192 NM_001282979 NM_001282980 NM_001282981 NM_001282982 NM_005078 NM_020908 XM_005254633 XM_006720662 XM_006720663 XM_006720664 XM_006720665
HUGO
OMIM
CCDS CCDS45293 CCDS45294 CCDS58375 CCDS61689 CCDS61691 CCDS61692 CCDS73747
HPRD 02558
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca