InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLE3

Summary

InnateDB Protein

IDBP-584798.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLE3

Protein Name

transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)

Synonyms

ESG; ESG3; GRG3; HsT18976;

Species

Homo sapiens

Ensembl Protein

ENSP00000452871

InnateDB Gene

IDBG-19521 (TLE3)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Placenta and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	29 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007219	Notch signaling pathway
GO:0009887	organ morphogenesis
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR005617 Groucho/TLE, N-terminal Q-rich domain
IPR009146 Groucho/transducin-like enhancer
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF03920

PRINTS

PR01850

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt