InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptpro

Summary

InnateDB Gene

IDBG-195285.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpro

Gene Name

protein tyrosine phosphatase, receptor type, O

Synonyms

D28; GLEPP1; PTPBK; Ptpn15; PTPoc; PTPphi; PTPROt; PTPU2; R-PTP-O

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030223

Encoded Proteins

IDBP-195287

protein tyrosine phosphatase, receptor type, O

IDBP-621534

protein tyrosine phosphatase, receptor type, O

IDBP-621535

protein tyrosine phosphatase, receptor type, O

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151490:
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:137252299-137464629

Strand

Forward strand

Band

Transcripts

ENSMUST00000077115	ENSMUSP00000076364
ENSMUST00000167679	ENSMUSP00000127112
ENSMUST00000167002	ENSMUSP00000131764

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017147	Wnt-protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0002548	monocyte chemotaxis
GO:0003093	regulation of glomerular filtration
GO:0003105	negative regulation of glomerular filtration
GO:0006470	protein dephosphorylation
GO:0007411	axon guidance
GO:0016311	dephosphorylation
GO:0030032	lamellipodium assembly
GO:0032835	glomerulus development
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0036060	slit diaphragm assembly
GO:0072112	glomerular visceral epithelial cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000151490

View Gene Order

ENSBTAG00000006256

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

kitpathway

Signaling events mediated by Stem cell factor receptor (c-Kit)

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.150490 Mm.186361 Mm.410129

RefSeq

NM_001164401 NM_001164402 NM_001164403 NM_011216

OMIM

CCDS

CCDS20664 CCDS51943 CCDS51944

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas