Mus musculus Gene: Ptpro
Summary
InnateDB Gene IDBG-195285.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptpro
Gene Name protein tyrosine phosphatase, receptor type, O
Synonyms D28; GLEPP1; PTPBK; Ptpn15; PTPoc; PTPphi; PTPROt; PTPU2; R-PTP-O;
Species Mus musculus
Ensembl Gene ENSMUSG00000030223
Encoded Proteins
protein tyrosine phosphatase, receptor type, O
protein tyrosine phosphatase, receptor type, O
protein tyrosine phosphatase, receptor type, O
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151490:
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:137252299-137464629
Strand Forward strand
Band G1
Transcripts
ENSMUST00000077115 ENSMUSP00000076364
ENSMUST00000167679 ENSMUSP00000127112
ENSMUST00000167002 ENSMUSP00000131764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0017147 Wnt-protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000902 cell morphogenesis
GO:0002548 monocyte chemotaxis
GO:0003093 regulation of glomerular filtration
GO:0003105 negative regulation of glomerular filtration
GO:0006470 protein dephosphorylation
GO:0007411 axon guidance
GO:0016311 dephosphorylation
GO:0030032 lamellipodium assembly
GO:0032835 glomerulus development
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0036060 slit diaphragm assembly
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0043197 dendritic spine
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt E9Q612
TrEMBL E9PVJ6 E9Q4I1 Q68FL5 Q6P4T4 Q80UH9 Q80W11
UniProt Splice Variant
Entrez Gene 19277
UniGene Mm.150490 Mm.186361 Mm.410129
RefSeq NM_001164401 NM_001164402 NM_001164403 NM_011216
OMIM
CCDS CCDS20664 CCDS51943 CCDS51944
HPRD
IMGT
MGI ID MGI:1097152
MGI Symbol Ptpro
EMBL AC093120 AC144767 AC163627 AH012592 BC051976 BC052743 BC063258 BC079649
GenPept AAH51976 AAH52743 AAH63258 AAH79649 AAO52748
RNA Seq Atlas 19277