Mus musculus Gene: Ptprc
Summary
InnateDB Gene IDBG-195821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptprc
Gene Name protein tyrosine phosphatase, receptor type, C
Synonyms B220; Cd45; CD45R; L-CA; loc; Ly-5; Lyt-4; T200;
Species Mus musculus
Ensembl Gene ENSMUSG00000026395
Encoded Proteins
protein tyrosine phosphatase, receptor type, C
protein tyrosine phosphatase, receptor type, C
protein tyrosine phosphatase, receptor type, C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] PTPRC (CD45) suppresses JAK (Janus kinase) kinases and negatively regulates cytokine receptor signaling by regulating interleukin-3-mediated cellular proliferation, erythropoietin-dependent haematopoiesis and antiviral responses in vitro and in vivo.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081237:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:138063407-138175706
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000112036
ENSMUST00000182755 ENSMUSP00000138275
ENSMUST00000182283 ENSMUSP00000138800
ENSMUST00000183301 ENSMUSP00000138350
ENSMUST00000188596
ENSMUST00000187586
ENSMUST00000183262
ENSMUST00000182138
ENSMUST00000183229
ENSMUST00000185570
ENSMUST00000186628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0043395 heparan sulfate proteoglycan binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002378 immunoglobulin biosynthetic process
GO:0002711 positive regulation of T cell mediated immunity
GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006469 negative regulation of protein kinase activity
GO:0006470 protein dephosphorylation
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 leukocyte cell-cell adhesion
GO:0010332 response to gamma radiation
GO:0016311 dephosphorylation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0031953 negative regulation of protein autophosphorylation
GO:0034113 heterotypic cell-cell adhesion
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0043410 positive regulation of MAPK cascade
GO:0044770 cell cycle phase transition
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045577 regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048539 bone marrow development
GO:0048864 stem cell development
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:2000473 positive regulation of hematopoietic stem cell migration
GO:2000648 positive regulation of stem cell proliferation
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Phosphorylation of CD3 and TCR zeta chains pathway
Immune System pathway
Axon guidance pathway
Adaptive Immune System pathway
Developmental Biology pathway
Semaphorin interactions pathway
Other semaphorin interactions pathway
TCR signaling pathway
KEGG
Cell adhesion molecules (CAMs) pathway
T cell receptor signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
BCR pathway
IL3 pathway
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
T cell receptor signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
Role of mef2d in t-cell apoptosis [Biocarta view]
Lck and fyn tyrosine kinases in initiation of tcr activation [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
TCR signaling in na´ve CD8+ T cells
CXCR4-mediated signaling events
TCR signaling in na´ve CD4+ T cells
BCR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.391573 Mm.413308
RefSeq NM_001111316 NM_001268286 NM_011210 XM_006529257 XM_006529258 XM_006529259 XM_006529260 XM_006529261 XM_006529262
OMIM
CCDS CCDS15330 CCDS48383 CCDS59542
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas