InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Alas1

Summary

InnateDB Gene

IDBG-195828.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alas1

Gene Name

aminolevulinic acid synthase 1

Synonyms

ALAS; Alas-1; Alas-h; ALAS-N

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032786

Encoded Proteins

IDBP-195830

aminolevulinic acid synthase 1

IDBP-255839

aminolevulinic acid synthase 1

IDBP-537087

aminolevulinic acid synthase 1

IDBP-542434

aminolevulinic acid synthase 1

IDBP-539724

aminolevulinic acid synthase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023330:
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:106233455-106248126

Strand

Reverse strand

Band

Transcripts

ENSMUST00000074082	ENSMUSP00000073725
ENSMUST00000112524	ENSMUSP00000108143
ENSMUST00000141118	ENSMUSP00000117014
ENSMUST00000134053
ENSMUST00000143125	ENSMUSP00000119968
ENSMUST00000123115
ENSMUST00000123601
ENSMUST00000133617	ENSMUSP00000122117

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003870	5-aminolevulinate synthase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006778	porphyrin-containing compound metabolic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0033014	tetrapyrrole biosynthetic process