Mus musculus Gene: Prim1
Summary
InnateDB Gene IDBG-196330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prim1
Gene Name DNA primase, p49 subunit
Synonyms AI324982;
Species Mus musculus
Ensembl Gene ENSMUSG00000025395
Encoded Proteins
DNA primase, p49 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198056:
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128015168-128030037
Strand Forward strand
Band D3
Transcripts
ENSMUST00000026461 ENSMUSP00000026461
ENSMUST00000133285
ENSMUST00000135580
ENSMUST00000138330
ENSMUST00000178041 ENSMUSP00000136556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003896 DNA primase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006269 DNA replication, synthesis of RNA primer
Cellular Component
GO:0016020 membrane
GO:1990077 primosome complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processive synthesis on the lagging strand pathway
Removal of the Flap Intermediate pathway
Cell Cycle, Mitotic pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
DNA strand elongation pathway
Telomere C-strand synthesis initiation pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
DNA Replication pathway
Telomere Maintenance pathway
Cell Cycle pathway
Activation of the pre-replicative complex pathway
Leading Strand Synthesis pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
M/G1 Transition pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Extension of Telomeres pathway
DNA replication initiation pathway
Polymerase switching pathway
E2F mediated regulation of DNA replication pathway
Lagging Strand Synthesis pathway
DNA Replication Pre-Initiation pathway
Polymerase switching on the C-strand of the telomere pathway
S Phase pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
DNA replication pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DNA Replication pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
DNA replication initiation pathway
Synthesis of DNA pathway
Telomere C-strand synthesis initiation pathway
Removal of the Flap Intermediate pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Chromosome Maintenance pathway
Polymerase switching pathway
DNA Replication Pre-Initiation pathway
Telomere Maintenance pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Cell Cycle pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
E2F mediated regulation of DNA replication pathway
Processive synthesis on the lagging strand pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Leading Strand Synthesis pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
DNA replication pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.2903
RefSeq NM_008921
OMIM
CCDS CCDS36086
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas