Version 5.4
Mus musculus Gene: Xdh
Summary
InnateDB Gene IDBG-197509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Xdh
Gene Name xanthine dehydrogenase
Synonyms XO; Xor; Xox-1; Xox1
Species Mus musculus
Ensembl Gene ENSMUSG00000024066
Encoded Proteins
IDBP-197511
xanthine dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20632067
[Homo sapiens] XDH (xanthine oxidase) is involved in TLR7/8-mediated activation of CASP1 and IL1B in an HIF1A-dependent manner.
Entrez Gene
Summary This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as xanthine oxidase, and functions in purine degradation. Additional studies also suggest a role in adipogenesis, and a function as a structural protein in milk fat droplets in the lactating mammary gland. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:73883908-73950182
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000024866 ENSMUSP00000024866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004854 xanthine dehydrogenase activity
GO:0004855 xanthine oxidase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0030151 molybdenum ion binding
GO:0042803 protein homodimerization activity
GO:0043546 molybdopterin cofactor binding
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007595 lactation
GO:0009115 xanthine catabolic process
GO:0010629 negative regulation of gene expression
GO:0030856 regulation of epithelial cell differentiation
GO:0045602 negative regulation of endothelial cell differentiation
GO:0051898 negative regulation of protein kinase B signaling
GO:0055114 oxidation-reduction process
GO:1900745 positive regulation of p38MAPK cascade
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001213 negative regulation of vasculogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005777 peroxisome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158125
View Gene Order
ENSBTAG00000012519
Not yet available
Pathways
NETPATH
REACTOME
REACT_263730
Purine metabolism pathway
REACT_188937
Metabolism pathway
REACT_245662
Metabolism of nucleotides pathway
REACT_253802
Purine catabolism pathway
KEGG
mmu00232
Caffeine metabolism pathway
mmu00230
Purine metabolism pathway
mmu00983
Drug metabolism pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_2086
Purine catabolism pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
hsa00232
Caffeine metabolism pathway
hsa00983
Drug metabolism pathway
hsa04146
Peroxisome pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt Q00519
TrEMBL Q99KV3 Q9CVF2
UniProt Splice Variant
Entrez Gene 22436
UniGene Mm.11223
RefSeq NM_011723
OMIM
CCDS CCDS28967
HPRD
IMGT
MGI ID MGI:98973
MGI Symbol Xdh
EMBL AC159187 AK008517 BC003997 CT025731 X62932 X75119 X75120 X75121 X75122 X75123 X75124 X75125 X75126 X75127 X75128 X75129 X75130 X75131 X75132 X75133 X75134 X75135 X75136 X75137 X75138 X75139 X75140 X75141 X75142 X75143 X75144 X75145 X75146 X75147 X75148 X75149 X75150 X75151 X75152 X75153 X75154
GenPept AAH03997 BAB25715 CAA44705 CAA52997
RNA Seq Atlas 22436

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca