InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: XDH

Summary

InnateDB Gene

IDBG-631874.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XDH

Gene Name

xanthine dehydrogenase/oxidase

Synonyms

XOR

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012519

Encoded Proteins

IDBP-683494

xanthine dehydrogenase/oxidase

IDBP-683499

xanthine dehydrogenase/oxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20632067

[Homo sapiens] XDH (xanthine oxidase) is involved in TLR7/8-mediated activation of CASP1 and IL1B in an HIF1A-dependent manner.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158125:
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jul 2008]
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:14176298-14281717

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016620	ENSBTAP00000016620
ENSBTAT00000032589	ENSBTAP00000032520

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004854	xanthine dehydrogenase activity
GO:0004855	xanthine oxidase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
GO:0042803	protein homodimerization activity
GO:0043546	molybdopterin cofactor binding
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0001937	negative regulation of endothelial cell proliferation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007595	lactation
GO:0009115	xanthine catabolic process
GO:0010629	negative regulation of gene expression
GO:0030856	regulation of epithelial cell differentiation
GO:0045602	negative regulation of endothelial cell differentiation
GO:0051898	negative regulation of protein kinase B signaling
GO:0055114	oxidation-reduction process
GO:1900745	positive regulation of p38MAPK cascade
GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2001213	negative regulation of vasculogenesis