InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Meis2

Summary

InnateDB Gene

IDBG-197577.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Meis2

Gene Name

Meis homeobox 2

Synonyms

A430109D20Rik; Mrg1; Stra10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027210

Encoded Proteins

IDBP-197579

Meis homeobox 2

IDBP-197581

Meis homeobox 2

IDBP-197583

Meis homeobox 2

IDBP-259250

Meis homeobox 2

IDBP-259252

Meis homeobox 2

IDBP-259254

Meis homeobox 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134138:
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a homeobox protein belonging to the TALE (\'three amino acid loop extension\') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:115863064-116065839

Strand

Reverse strand

Band

Transcripts

ENSMUST00000102538	ENSMUSP00000099597
ENSMUST00000028639	ENSMUSP00000028639
ENSMUST00000074285	ENSMUSP00000073898
ENSMUST00000110908	ENSMUSP00000106533
ENSMUST00000110907	ENSMUSP00000106532
ENSMUST00000110906	ENSMUSP00000106531
ENSMUST00000120995
ENSMUST00000118654
ENSMUST00000151279
ENSMUST00000149217
ENSMUST00000150477
ENSMUST00000154671
ENSMUST00000140461
ENSMUST00000135543
ENSMUST00000134314
ENSMUST00000138526
ENSMUST00000133990
ENSMUST00000177493
ENSMUST00000189640

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	11 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001654	eye development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009612	response to mechanical stimulus
GO:0031016	pancreas development
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070848	response to growth factor

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000134138

View Gene Order

ENSBTAG00000003172

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.247566

RefSeq

NM_001136072 NM_001159567 NM_001159568 NM_001159569 NM_001159570 NM_010825 XM_006498866 XM_006498867

OMIM

CCDS

CCDS16568 CCDS50664 CCDS50665 CCDS50666 CCDS50667 CCDS50668

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas