Mus musculus Protein: Meis2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-259250.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Meis2 | ||||||||||||||||||||||
Protein Name | Meis homeobox 2 | ||||||||||||||||||||||
Synonyms | A430109D20Rik; Mrg1; Stra10; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000106533 | ||||||||||||||||||||||
InnateDB Gene | IDBG-197577 (Meis2) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoforms 3/Meis2B and 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription. {ECO:0000269PubMed:11279116, ECO:0000269PubMed:11438208, ECO:0000269PubMed:17178831}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:9710595}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Displays spatially restricted expression patterns in the developing nervous system, limbs, face, and in various viscera. In adult, it is mainly expressed in the brain and female genital tract, with a different distribution of the alternative splice forms in these organs. Lower expression in lung and only basal level in heart, liver, kidney, spleen, and testis. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:108564 | ||||||||||||||||||||||
InterPro |
IPR001356
Homeobox domain IPR008422 Homeobox KN domain IPR009057 Homeodomain-like |
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PFAM |
PF00046
PF05920 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00389
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P97367 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P97367 | ||||||||||||||||||||||
TrEMBL | Q3UJ35 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 17536 | ||||||||||||||||||||||
UniGene | Mm.247566 | ||||||||||||||||||||||
RefSeq | NP_001129544 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Meis2 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS50666 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AJ000504 AJ000505 AJ000506 AJ000507 AK146633 U57343 U68383 U68384 | ||||||||||||||||||||||
GenPept | AAB19193 AAB19194 AAC52948 BAE27320 CAA04138 CAA04139 CAA04140 CAA04141 | ||||||||||||||||||||||