Version 5.4
Mus musculus Gene: Sh3glb1
Summary
InnateDB Gene IDBG-197628.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3glb1
Gene Name SH3-domain GRB2-like B1 (endophilin)
Synonyms AA409932; AI314629; AU015566; Bif-1; mKIAA0491
Species Mus musculus
Ensembl Gene ENSMUSG00000037062
Encoded Proteins
IDBP-621413
SH3-domain GRB2-like B1 (endophilin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000097033:
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:144688844-144720323
Strand Reverse strand
Band H2
Transcripts
ENSMUST00000163279 ENSMUSP00000129800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0042171 lysophosphatidic acid acyltransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006915 apoptotic process
GO:0008654 phospholipid biosynthetic process
GO:0032461 positive regulation of protein oligomerization
GO:0051084 'de novo' posttranslational protein folding
GO:0051259 protein oligomerization
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005740 mitochondrial envelope
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000097033
View Gene Order
ENSBTAG00000031171
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.413830
RefSeq NM_019464
OMIM
CCDS CCDS17885
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca