Homo sapiens Gene: SH3GLB1
Summary
InnateDB Gene IDBG-100094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3GLB1
Gene Name SH3-domain GRB2-like endophilin B1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000097033
Encoded Proteins
SH3-domain GRB2-like endophilin B1
SH3-domain GRB2-like endophilin B1
SH3-domain GRB2-like endophilin B1
SH3-domain GRB2-like endophilin B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:86704570-86748184
Strand Forward strand
Band p22.3
Transcripts
ENST00000370558 ENSP00000473267
ENST00000482504 ENSP00000418744
ENST00000535010 ENSP00000441355
ENST00000602603
ENST00000616170 ENSP00000479919
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0042171 lysophosphatidic acid acyltransferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006915 apoptotic process
GO:0008654 phospholipid biosynthetic process
GO:0032461 positive regulation of protein oligomerization
GO:0051084 'de novo' posttranslational protein folding
GO:0051259 protein oligomerization
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y371
TrEMBL
UniProt Splice Variant
Entrez Gene 51100
UniGene Hs.136309
RefSeq NM_001206652 NM_001206651 NM_001206653 NM_016009
HUGO HGNC:10833
OMIM 609287
CCDS CCDS55612 CCDS55613 CCDS710 CCDS72819
HPRD 15333
IMGT
EMBL AB007960 AF151819 AF257318 AF263293 AF350371 AK001954 AK303710 AL049597 BC007455
GenPept AAD34056 AAF73017 AAF81225 AAH07455 AAK27365 BAA91999 BAD88797 BAG64694 CAC10394 CAC10395
RNA Seq Atlas 51100