Mus musculus Gene: Kras
Summary
InnateDB Gene IDBG-197719.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kras
Gene Name v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Synonyms AI929937; K-ras; Ki-ras; Kras-2; Kras2; p21B; ras;
Species Mus musculus
Ensembl Gene ENSMUSG00000030265
Encoded Proteins
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133703:
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:145216699-145250239
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000032399 ENSMUSP00000032399
ENSMUST00000111710 ENSMUSP00000107339
ENSMUST00000123972
ENSMUST00000156486 ENSMUSP00000119414
ENSMUST00000149314
ENSMUST00000155145 ENSMUSP00000118251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008022 protein C-terminus binding
GO:0019002 GMP binding
GO:0019003 GDP binding
GO:0030275 LRR domain binding
GO:0032403 protein complex binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008542 visual learning
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0015031 protein transport
GO:0019221 cytokine-mediated signaling pathway
GO:0030036 actin cytoskeleton organization
GO:0030335 positive regulation of cell migration
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032855 positive regulation of Rac GTPase activity
GO:0034259 negative regulation of Rho GTPase activity
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035176 social behavior
GO:0043406 positive regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051291 protein heterooligomerization
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090303 positive regulation of wound healing
GO:0090398 cellular senescence
GO:1900029 positive regulation of ruffle assembly
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000630 positive regulation of miRNA metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Disease pathway
SHC-related events pathway
RAF/MAP kinase cascade pathway
Hemostasis pathway
Signaling by constitutively active EGFR pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
RAF phosphorylates MEK pathway
Signaling by VEGF pathway
EGFR Transactivation by Gastrin pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB2 signaling pathway
Cytokine Signaling in Immune system pathway
VEGFR2 mediated cell proliferation pathway
Cell surface interactions at the vascular wall pathway
Immune System pathway
SHC-mediated signalling pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
SHC1 events in ERBB4 signaling pathway
Signalling to RAS pathway
SHC1 events in EGFR signaling pathway
RAF activation pathway
Activation of RAS in B cells pathway
Signaling by EGFR pathway
Frs2-mediated activation pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
p38MAPK events pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Signaling by FGFR mutants pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
Developmental Biology pathway
SHC-mediated cascade pathway
SOS-mediated signalling pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
ARMS-mediated activation pathway
Signal Transduction pathway
GRB2 events in ERBB2 signaling pathway
Signaling by Leptin pathway
Prolonged ERK activation events pathway
Tie2 Signaling pathway
Signaling by FGFR pathway
GRB2 events in EGFR signaling pathway
FCERI mediated MAPK activation pathway
MEK activation pathway
SHC-related events triggered by IGF1R pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
Signalling to p38 via RIT and RIN pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Dorso-ventral axis formation pathway
Axon guidance pathway
VEGF signaling pathway pathway
Tight junction pathway
Gap junction pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Aldosterone-regulated sodium reabsorption pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
NGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF8 signaling (Mouse) pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
SHC-related events pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signalling to p38 via RIT and RIN pathway
FRS2-mediated cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
Activation of RAS in B cells pathway
p38MAPK events pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
Signaling by constitutively active EGFR pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
RAF activation pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
SHC-related events triggered by IGF1R pathway
Signaling by SCF-KIT pathway
Frs2-mediated activation pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Tie2 Signaling pathway
IRS-mediated signalling pathway
SHC1 events in EGFR signaling pathway
Adaptive Immune System pathway
SHC-mediated signalling pathway
Immune System pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
VEGFR2 mediated cell proliferation pathway
Insulin receptor signalling cascade pathway
Interleukin-2 signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
SHC-mediated cascade pathway
IRS-related events pathway
SHC1 events in ERBB2 signaling pathway
IGF1R signaling cascade pathway
ARMS-mediated activation pathway
EGFR Transactivation by Gastrin pathway
Prolonged ERK activation events pathway
Signaling by FGFR pathway
Signalling to RAS pathway
Signaling by PDGF pathway
MEK activation pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Cell surface interactions at the vascular wall pathway
Disease pathway
RAF phosphorylates MEK pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Dorso-ventral axis formation pathway
Axon guidance pathway
VEGF signaling pathway pathway
Tight junction pathway
Gap junction pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Aldosterone-regulated sodium reabsorption pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Telomeres telomerase cellular aging and immortality [Biocarta view]
PID NCI
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.383182 Mm.396389 Mm.397457 Mm.46847
RefSeq NM_021284
OMIM
CCDS CCDS20693
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas