InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kras

Summary

InnateDB Gene

IDBG-197719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kras

Gene Name

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Synonyms

AI929937; K-ras; Ki-ras; Kras-2; Kras2; p21B; ras

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030265

Encoded Proteins

IDBP-197721

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

IDBP-257546

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

IDBP-541187

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

IDBP-541446

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133703:
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:145216699-145250239

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032399	ENSMUSP00000032399
ENSMUST00000111710	ENSMUSP00000107339
ENSMUST00000123972
ENSMUST00000156486	ENSMUSP00000119414
ENSMUST00000149314
ENSMUST00000155145	ENSMUSP00000118251

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008022	protein C-terminus binding
GO:0019002	GMP binding
GO:0019003	GDP binding
GO:0030275	LRR domain binding
GO:0032403	protein complex binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0007093	mitotic cell cycle checkpoint
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008542	visual learning
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0015031	protein transport
GO:0019221	cytokine-mediated signaling pathway
GO:0030036	actin cytoskeleton organization
GO:0030335	positive regulation of cell migration
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0032855	positive regulation of Rac GTPase activity
GO:0034259	negative regulation of Rho GTPase activity
GO:0035022	positive regulation of Rac protein signal transduction
GO:0035176	social behavior
GO:0043406	positive regulation of MAP kinase activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0045596	negative regulation of cell differentiation
GO:0045740	positive regulation of DNA replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051146	striated muscle cell differentiation
GO:0051291	protein heterooligomerization
GO:0051384	response to glucocorticoid
GO:0051385	response to mineralocorticoid
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090303	positive regulation of wound healing
GO:0090398	cellular senescence
GO:1900029	positive regulation of ruffle assembly
GO:2000251	positive regulation of actin cytoskeleton reorganization
GO:2000630	positive regulation of miRNA metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0045121	membrane raft

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000133703

View Gene Order

ENSBTAG00000009778

Not yet available

Pathways

NETPATH

REACTOME

REACT_239142

Innate Immune System pathway

REACT_188199

Signaling by the B Cell Receptor (BCR) pathway

REACT_188191

Signaling by ERBB2 pathway

REACT_189085

Disease pathway

REACT_252337

SHC-related events pathway

REACT_242240

RAF/MAP kinase cascade pathway

REACT_224553

Hemostasis pathway

REACT_199123

Signaling by constitutively active EGFR pathway

REACT_254215

Signaling by GPCR pathway

REACT_240250

Signaling by Insulin receptor pathway

REACT_261365

Interleukin-2 signaling pathway

REACT_257146

RAF phosphorylates MEK pathway

REACT_227951

Signaling by VEGF pathway

REACT_198350

EGFR Transactivation by Gastrin pathway

REACT_188177

Signaling by FGFR in disease pathway

REACT_188579

Signaling by ERBB4 pathway

REACT_188578

Signaling by SCF-KIT pathway

REACT_188573

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_188574

SHC1 events in ERBB2 signaling pathway

REACT_233584

Cytokine Signaling in Immune system pathway

REACT_245086

VEGFR2 mediated cell proliferation pathway

REACT_225233

Cell surface interactions at the vascular wall pathway

REACT_230745

Immune System pathway

REACT_239466

SHC-mediated signalling pathway

REACT_230639

Downstream signal transduction pathway

REACT_231729

Downstream signaling of activated FGFR pathway

REACT_188580

SHC1 events in ERBB4 signaling pathway

REACT_239722

Signalling to RAS pathway

REACT_260286

SHC1 events in EGFR signaling pathway

REACT_237640

RAF activation pathway

REACT_199122

Activation of RAS in B cells pathway

REACT_242976

Signaling by EGFR pathway

REACT_262560

Frs2-mediated activation pathway

REACT_259732

Insulin receptor signalling cascade pathway

REACT_188215

IRS-related events triggered by IGF1R pathway

REACT_188218

IGF1R signaling cascade pathway

REACT_188219

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway

REACT_207601

p38MAPK events pathway

REACT_257088

VEGFA-VEGFR2 Pathway pathway

REACT_261444

Axon guidance pathway

REACT_188204

Fc epsilon receptor (FCERI) signaling pathway

REACT_231290

Signalling to ERKs pathway

REACT_261687

Signaling by Interleukins pathway

REACT_196455

Signaling by FGFR mutants pathway

REACT_248921

Signalling by NGF pathway

REACT_229531

Adaptive Immune System pathway

REACT_263353

Signaling by PDGF pathway

REACT_234357

FRS2-mediated cascade pathway

REACT_188576

Developmental Biology pathway

REACT_94437

SHC-mediated cascade pathway

REACT_241824

SOS-mediated signalling pathway

REACT_243154

IRS-related events pathway

REACT_237883

NGF signalling via TRKA from the plasma membrane pathway

REACT_242206

IRS-mediated signalling pathway

REACT_234035

ARMS-mediated activation pathway

REACT_188257

Signal Transduction pathway

REACT_188528

GRB2 events in ERBB2 signaling pathway

REACT_188529

Signaling by Leptin pathway

REACT_250933

Prolonged ERK activation events pathway

REACT_211860

Tie2 Signaling pathway

REACT_242456

Signaling by FGFR pathway

REACT_245103

GRB2 events in EGFR signaling pathway

REACT_188530

FCERI mediated MAPK activation pathway

REACT_247566

MEK activation pathway

REACT_188220

SHC-related events triggered by IGF1R pathway

REACT_188180

Signaling by EGFR in Cancer pathway

REACT_237796

NCAM signaling for neurite out-growth pathway

REACT_252757

Signalling to p38 via RIT and RIN pathway

REACT_209507

Downstream signaling events of B Cell Receptor (BCR) pathway

REACT_188188

DAP12 interactions pathway

REACT_188185

DAP12 signaling pathway

KEGG

mmu04530

Tight junction pathway

mmu05213

Endometrial cancer pathway

mmu04360

Axon guidance pathway

mmu05219

Bladder cancer pathway

mmu05211

Renal cell carcinoma pathway

mmu04012

ErbB signaling pathway pathway

mmu04370

VEGF signaling pathway pathway

mmu04910

Insulin signaling pathway pathway

mmu05221

Acute myeloid leukemia pathway

mmu04660

T cell receptor signaling pathway pathway

mmu04916

Melanogenesis pathway

mmu04540

Gap junction pathway

mmu05210

Colorectal cancer pathway

mmu05216

Thyroid cancer pathway

mmu04664

Fc epsilon RI signaling pathway pathway

mmu05218

Melanoma pathway

mmu04650

Natural killer cell mediated cytotoxicity pathway

mmu04912

GnRH signaling pathway pathway

mmu04810

Regulation of actin cytoskeleton pathway

mmu04010

MAPK signaling pathway pathway

mmu04720

Long-term potentiation pathway

mmu05214

Glioma pathway

mmu05215

Prostate cancer pathway

mmu04730

Long-term depression pathway

mmu05220

Chronic myeloid leukemia pathway

mmu05223

Non-small cell lung cancer pathway

mmu04662

B cell receptor signaling pathway pathway

mmu05212

Pancreatic cancer pathway

mmu04062

Chemokine signaling pathway pathway

mmu04722

Neurotrophin signaling pathway pathway

mmu04320

Dorso-ventral axis formation pathway

mmu05200

Pathways in cancer pathway

mmu04914

Progesterone-mediated oocyte maturation pathway

mmu04960

Aldosterone-regulated sodium reabsorption pathway

mmu05160

Hepatitis C pathway

INOH