Homo sapiens Gene: KRAS
InnateDB Gene IDBG-23889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRAS
Gene Name v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Species Homo sapiens
Ensembl Gene ENSG00000133703
Encoded Proteins
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:25204789-25250936
Strand Reverse strand
Band p12.1
ENST00000256078 ENSP00000256078
ENST00000311936 ENSP00000308495
ENST00000557334 ENSP00000452512
ENST00000556131 ENSP00000451856
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 55 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 3 [view]
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019002 GMP binding
GO:0019003 GDP binding
GO:0030275 LRR domain binding
GO:0032403 protein complex binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0001934 positive regulation of protein phosphorylation
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008542 visual learning
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0015031 protein transport
GO:0019221 cytokine-mediated signaling pathway
GO:0030036 actin cytoskeleton organization
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035176 social behavior
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043406 positive regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response
GO:0045596 negative regulation of cell differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050900 leukocyte migration
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0060441 epithelial tube branching involved in lung morphogenesis
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045121 membrane raft
Mus musculus
Bos taurus
Gene ID
Gene Order
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
EGFR1 pathway
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
SHC-related events pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signalling to p38 via RIT and RIN pathway
FRS2-mediated cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
Activation of RAS in B cells pathway
p38MAPK events pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
Signaling by constitutively active EGFR pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
RAF activation pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
SHC-related events triggered by IGF1R pathway
Signaling by SCF-KIT pathway
Frs2-mediated activation pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Tie2 Signaling pathway
IRS-mediated signalling pathway
SHC1 events in EGFR signaling pathway
Adaptive Immune System pathway
SHC-mediated signalling pathway
Immune System pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
VEGFR2 mediated cell proliferation pathway
Insulin receptor signalling cascade pathway
Interleukin-2 signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
SHC-mediated cascade pathway
IRS-related events pathway
SHC1 events in ERBB2 signaling pathway
IGF1R signaling cascade pathway
ARMS-mediated activation pathway
EGFR Transactivation by Gastrin pathway
Prolonged ERK activation events pathway
Signaling by FGFR pathway
Signalling to RAS pathway
Signaling by PDGF pathway
MEK activation pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Cell surface interactions at the vascular wall pathway
Disease pathway
RAF phosphorylates MEK pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Dorso-ventral axis formation pathway
Axon guidance pathway
VEGF signaling pathway pathway
Tight junction pathway
Gap junction pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Aldosterone-regulated sodium reabsorption pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
IGF1 signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
Telomeres telomerase cellular aging and immortality [Biocarta view]
Regulation of Ras family activation
UniProt Splice Variant
Entrez Gene
UniGene Hs.594741 Hs.675166 Hs.690627 Hs.691064 Hs.732231 Hs.734869
RefSeq NM_004985 NM_033360 XM_006719069
HPRD 01817
RNA Seq Atlas