Mus musculus Gene: Spast
InnateDB Gene IDBG-197793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spast
Gene Name spastin
Synonyms mKIAA1083; Spg4
Species Mus musculus
Ensembl Gene ENSMUSG00000024068
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000021574:
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74338987-74391113
Strand Forward strand
Band E2
ENSMUST00000024869 ENSMUSP00000024869
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008568 microtubule-severing ATPase activity
GO:0009378 four-way junction helicase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0043014 alpha-tubulin binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0001578 microtubule bundle formation
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0007109 cytokinesis, completion of separation
GO:0007409 axonogenesis
GO:0031117 positive regulation of microtubule depolymerization
GO:0034214 protein hexamerization
GO:0051013 microtubule severing
GO:0051260 protein homooligomerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005819 spindle
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0016021 integral component of membrane
GO:0030496 midbody
GO:0031410 cytoplasmic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
SwissProt Q9QYY8
UniProt Splice Variant
Entrez Gene 50850
UniGene Mm.19804
RefSeq NM_001162870 NM_016962
MGI ID MGI:1858896
MGI Symbol Spast
EMBL AJ246002 AK007793 AK129282 BC046286
GenPept AAH46286 BAB25259 BAC98092 CAB60143
RNA Seq Atlas 50850