Mus musculus Gene: Hnrnpr
Summary
InnateDB Gene IDBG-197957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnrnpr
Gene Name heterogeneous nuclear ribonucleoprotein R
Synonyms 2610003J05Rik; 2610528B01Rik; Hnrpr;
Species Mus musculus
Ensembl Gene ENSMUSG00000066037
Encoded Proteins
heterogeneous nuclear ribonucleoprotein R
heterogeneous nuclear ribonucleoprotein R
heterogeneous nuclear ribonucleoprotein R
heterogeneous nuclear ribonucleoprotein R
heterogeneous nuclear ribonucleoprotein R
heterogeneous nuclear ribonucleoprotein R
heterogeneous nuclear ribonucleoprotein R
heterogeneous nuclear ribonucleoprotein R
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125944:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:136310942-136345981
Strand Forward strand
Band D3
Transcripts
ENSMUST00000084219 ENSMUSP00000081239
ENSMUST00000105850 ENSMUSP00000101476
ENSMUST00000131671 ENSMUSP00000138263
ENSMUST00000148843 ENSMUSP00000138399
ENSMUST00000145282 ENSMUSP00000138859
ENSMUST00000125696 ENSMUSP00000138190
ENSMUST00000134524 ENSMUSP00000119666
ENSMUST00000156259 ENSMUSP00000117096
ENSMUST00000153505
ENSMUST00000182327
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 121 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0019013 viral nucleocapsid
GO:0030529 ribonucleoprotein complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL A2AW40 A2AW41 F7B5B5 Q8BL32 Q8VHM5 S4R1E9
UniProt Splice Variant
Entrez Gene 74326
UniGene
RefSeq NM_001277121 NM_001277122 NM_001277123 XM_006539221 NM_028871 XM_006539222 XM_006539226 XM_006539227 XM_006539228
OMIM
CCDS CCDS18805 CCDS71495
HPRD
IMGT
MGI ID MGI:1891692
MGI Symbol Hnrnpr
EMBL AF441128 AK046495 AL670673 AL935264 BC038051 BX537311
GenPept AAH38051 AAL35332 BAC32756
RNA Seq Atlas 74326