Version 5.4
Mus musculus Gene: Hnrnpr
Summary
InnateDB Gene IDBG-197957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnrnpr
Gene Name heterogeneous nuclear ribonucleoprotein R
Synonyms 2610003J05Rik; 2610528B01Rik; Hnrpr
Species Mus musculus
Ensembl Gene ENSMUSG00000066037
Encoded Proteins
IDBP-197961
heterogeneous nuclear ribonucleoprotein R
IDBP-269995
heterogeneous nuclear ribonucleoprotein R
IDBP-788103
heterogeneous nuclear ribonucleoprotein R
IDBP-788104
heterogeneous nuclear ribonucleoprotein R
IDBP-788105
heterogeneous nuclear ribonucleoprotein R
IDBP-788106
heterogeneous nuclear ribonucleoprotein R
IDBP-542011
heterogeneous nuclear ribonucleoprotein R
IDBP-535400
heterogeneous nuclear ribonucleoprotein R
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125944:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:136310942-136345981
Strand Forward strand
Band D3
Transcripts
ENSMUST00000084219 ENSMUSP00000081239
ENSMUST00000105850 ENSMUSP00000101476
ENSMUST00000131671 ENSMUSP00000138263
ENSMUST00000148843 ENSMUSP00000138399
ENSMUST00000145282 ENSMUSP00000138859
ENSMUST00000125696 ENSMUSP00000138190
ENSMUST00000134524 ENSMUSP00000119666
ENSMUST00000156259 ENSMUSP00000117096
ENSMUST00000153505
ENSMUST00000182327
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 121 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0019013 viral nucleocapsid
GO:0030529 ribonucleoprotein complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125944
View Gene Order
ENSBTAG00000016578
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2AW40
UniProt Splice Variant
Entrez Gene 74326
UniGene Mm.31051 Mm.313380 Mm.402394 Mm.406838
RefSeq NM_001277121 NM_001277122 NM_001277123 NM_028871 XM_006539221 XM_006539222 XM_006539226 XM_006539227 XM_006539228
OMIM
CCDS CCDS18805 CCDS71495
HPRD
IMGT
MGI ID MGI:1891692
MGI Symbol Hnrnpr
EMBL AL670673 AL935264 BX537311
GenPept
RNA Seq Atlas 74326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca