Version 5.4
Homo sapiens Gene: DDX3Y
Summary
InnateDB Gene IDBG-198.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX3Y
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000067048
Encoded Proteins
IDBP-200
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
IDBP-204
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
IDBP-361908
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
IDBP-361914
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome. The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome Y:12904108-12920478
Strand Forward strand
Band q11.221
Transcripts
ENST00000360160 ENSP00000353284
ENST00000336079 ENSP00000336725
ENST00000454054 ENSP00000398953
ENST00000440554 ENSP00000400377
ENST00000493363
ENST00000469101
ENST00000463199
ENST00000495478
ENST00000472510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
Biological Process
GO:0006200 ATP catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.99120
RefSeq NM_001122665 NM_004660 XM_005262564 XM_006724877
HUGO
OMIM
CCDS CCDS14782
HPRD 02452
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca