Version 5.4
Mus musculus Gene: Acsf3
Summary
InnateDB Gene IDBG-198008.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acsf3
Gene Name acyl-CoA synthetase family member 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000015016
Encoded Proteins
IDBP-198010
acyl-CoA synthetase family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176715:
This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:122775505-122817880
Strand Forward strand
Band E1
Transcripts
ENSMUST00000015160 ENSMUSP00000015160
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0016878 acid-thiol ligase activity
GO:0090409 malonyl-CoA synthetase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
GO:0090410 malonate catabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000176715
View Gene Order
ENSBTAG00000015968
Not yet available
Cross-References
SwissProt Q3URE1
TrEMBL
UniProt Splice Variant
Entrez Gene 257633
UniGene
RefSeq NM_144932 XM_006531030 XM_006531031 XM_006531032
OMIM
CCDS CCDS40505
HPRD
IMGT
MGI ID MGI:2182591
MGI Symbol Acsf3
EMBL AK141579 BC022709
GenPept AAH22709 BAE24747
RNA Seq Atlas 257633

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca