Version 5.4
Homo sapiens Gene: ACSF3
Summary
InnateDB Gene IDBG-47147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSF3
Gene Name acyl-CoA synthetase family member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176715
Encoded Proteins
IDBP-47149
acyl-CoA synthetase family member 3
IDBP-47151
acyl-CoA synthetase family member 3
IDBP-294371
acyl-CoA synthetase family member 3
IDBP-595648
acyl-CoA synthetase family member 3
IDBP-595796
acyl-CoA synthetase family member 3
IDBP-601145
acyl-CoA synthetase family member 3
IDBP-747089
IDBP-588170
acyl-CoA synthetase family member 3
IDBP-587562
acyl-CoA synthetase family member 3
IDBP-596643
acyl-CoA synthetase family member 3
IDBP-587680
acyl-CoA synthetase family member 3
IDBP-595763
acyl-CoA synthetase family member 3
IDBP-810061
acyl-CoA synthetase family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:89088375-89155846
Strand Forward strand
Band q24.3
Transcripts
ENST00000378345 ENSP00000367596
ENST00000317447 ENSP00000320646
ENST00000393145
ENST00000406948 ENSP00000384627
ENST00000537895 ENSP00000439201
ENST00000537290 ENSP00000440734
ENST00000540697 ENSP00000445397
ENST00000541755 ENSP00000457301
ENST00000542688 ENSP00000446281
ENST00000544543 ENSP00000442781
ENST00000538340 ENSP00000445870
ENST00000543676 ENSP00000442683
ENST00000537116
ENST00000537155
ENST00000535176 ENSP00000443428
ENST00000562204
ENST00000562750
ENST00000614302 ENSP00000479130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0016878 acid-thiol ligase activity
GO:0090409 malonyl-CoA synthetase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
GO:0090410 malonate catabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015016
View Gene Order
ENSBTAG00000015968
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.670100 Hs.737565
RefSeq NM_001127214 NM_001243279 NM_001284316 NM_174917
HUGO
OMIM
CCDS CCDS10974 CCDS73926
HPRD 14117
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca