InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ctsc

Summary

InnateDB Gene

IDBG-198191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctsc

Gene Name

cathepsin C

Synonyms

AI047818; DPP1; DPPI

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030560

Encoded Proteins

IDBP-198193

cathepsin C

IDBP-538172

cathepsin C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109861:
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:88278085-88310888

Strand

Forward strand

Band

Transcripts

ENSMUST00000032779	ENSMUSP00000032779
ENSMUST00000128791	ENSMUSP00000119503
ENSMUST00000131108
ENSMUST00000139159
ENSMUST00000152834

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016505	peptidase activator activity involved in apoptotic process
GO:0019902	phosphatase binding
GO:0031404	chloride ion binding
GO:0042802	identical protein binding
GO:0043621	protein self-association
GO:0051087	chaperone binding

Biological Process

GO:0001913	T cell mediated cytotoxicity
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007568	aging
GO:0010033	response to organic substance
GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005764	lysosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000109861

View Gene Order

ENSBTAG00000011100

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04142

Lysosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04142

Lysosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.322945 Mm.421976

RefSeq

NM_009982

OMIM

CCDS

CCDS21438

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas