InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctsc

Summary

InnateDB Protein

IDBP-198193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctsc

Protein Name

cathepsin C

Synonyms

AI047818; DPP1; DPPI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032779

InnateDB Gene

IDBG-198191 (Ctsc)

Protein Structure

UniProt Annotation

Function

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Broadly distributed, but higher levels found in lung, liver, kidney and spleen. Lower levels found in testis and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016505	peptidase activator activity involved in apoptotic process
GO:0019902	phosphatase binding
GO:0031404	chloride ion binding
GO:0042802	identical protein binding
GO:0043621	protein self-association
GO:0051087	chaperone binding

Biological Process

GO:0001913	T cell mediated cytotoxicity
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007568	aging
GO:0010033	response to organic substance
GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005764	lysosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome