Version 5.4
Mus musculus Gene: Pmel
Summary
InnateDB Gene IDBG-198208.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pmel
Gene Name premelanosome protein
Synonyms D10H12S53E; D12S53Eh; gp100; gp87; Pmel17; Si; Silv
Species Mus musculus
Ensembl Gene ENSMUSG00000025359
Encoded Proteins
IDBP-198210
premelanosome protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185664:
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128706258-128720238
Strand Forward strand
Band D3
Transcripts
ENSMUST00000054125 ENSMUSP00000051869
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0032438 melanosome organization
GO:0042438 melanin biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0032585 multivesicular body membrane
GO:0042470 melanosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185664
View Gene Order
ENSBTAG00000004019
Not yet available
Cross-References
SwissProt
TrEMBL Q9CZB2 Q9QY70
UniProt Splice Variant
Entrez Gene 20431
UniGene Mm.16756
RefSeq NM_021882 XM_006513405
OMIM
CCDS CCDS36091
HPRD
IMGT
MGI ID MGI:98301
MGI Symbol Pmel
EMBL AC117232 AC131081 AF118450 AK012808 AK131956 BC082555 CH466578
GenPept AAF19760 AAH82555 BAB28486 BAE20900 EDL24601 EDL24602
RNA Seq Atlas 20431

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca