InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dpep1

Summary

InnateDB Gene

IDBG-198378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpep1

Gene Name

dipeptidase 1 (renal)

Synonyms

AI327012; MBD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019278

Encoded Proteins

IDBP-198380

dipeptidase 1 (renal)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000015413:
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:123186235-123201810

Strand

Forward strand

Band

Transcripts

ENSMUST00000019422

ENSMUSP00000019422

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008239	dipeptidyl-peptidase activity
GO:0008270	zinc ion binding
GO:0016805	dipeptidase activity
GO:0034235	GPI anchor binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0070573	metallodipeptidase activity
GO:0072341	modified amino acid binding

Biological Process

GO:0006508	proteolysis
GO:0016999	antibiotic metabolic process
GO:0030336	negative regulation of cell migration
GO:0035690	cellular response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050667	homocysteine metabolic process
GO:0071277	cellular response to calcium ion
GO:0071732	cellular response to nitric oxide

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016324	apical plasma membrane
GO:0031225	anchored component of membrane
GO:0031528	microvillus membrane
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome