Mus musculus Gene: Dpep1
Summary
InnateDB Gene IDBG-198378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dpep1
Gene Name dipeptidase 1 (renal)
Synonyms AI327012; MBD;
Species Mus musculus
Ensembl Gene ENSMUSG00000019278
Encoded Proteins
dipeptidase 1 (renal)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000015413:
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:123186235-123201810
Strand Forward strand
Band E1
Transcripts
ENSMUST00000019422 ENSMUSP00000019422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0016805 dipeptidase activity
GO:0034235 GPI anchor binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0070573 metallodipeptidase activity
GO:0072341 modified amino acid binding
Biological Process
GO:0006508 proteolysis
GO:0016999 antibiotic metabolic process
GO:0030336 negative regulation of cell migration
GO:0035690 cellular response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050667 homocysteine metabolic process
GO:0071277 cellular response to calcium ion
GO:0071732 cellular response to nitric oxide
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0031528 microvillus membrane
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Aflatoxin activation and detoxification pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Biological oxidations pathway
Arachidonic acid metabolism pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Aflatoxin activation and detoxification pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Metabolism pathway
Biological oxidations pathway
Arachidonic acid metabolism pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Aflatoxin activation and detoxification pathway
Biological oxidations pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P31428
TrEMBL
UniProt Splice Variant
Entrez Gene 13479
UniGene Mm.20388
RefSeq NM_007876
OMIM
CCDS CCDS22750
HPRD
IMGT
MGI ID MGI:94917
MGI Symbol Dpep1
EMBL AC163617 CH466525 D13139
GenPept BAA02432 EDL11712
RNA Seq Atlas 13479